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  • Annals of Clinical Sciences
    Vol. 8 No. 2 (2023)

    ORIGINAL ARTICLE

    OUTCOMES AND COMPLICATIONS OF HEAD AND NECK MICROVASCULAR RECONSTRUCTION IN A RESOURCE LIMITING SETTING

    E. Okoturo

    Head and Neck Cancer Division, Oral and Maxillofacial Surgery Department, Lagos State University Teaching Hospital (LASUTH), Lagos, Nigeria; 2Lagos State University College of Medicine (LASUCOM), Lagos, Nigeria.

    Abstract

    Background: This is a study on the complications and outcomes of head and neck microvascular reconstruction in a resource limiting centre. The aim is to evaluate the impact of the events in this limiting environment on the outcome of free tissue transfer for head and neck reconstruction and how this can be prevented to help improve outcomes.

    Methodology: This was a retrospective cohort of cases seen over a 4- year period (2019-2022). All the patients that underwent free tissue transfer for head and neck ablative defects were included. The high-risk cases were evaluated using age > 60 years, Charlson comorbidity index and American Society of Anaesthesiologist (ASA) physical status evaluation scores as predicted variables. Outcomes and postoperative complications were also evaluated, and predictor variables analysed against complications.
    Results: Twenty-three cases underwent free tissue transfer for specific head and neck defects over the study period. Their median age was 53 years and male to female ratio was 2:1. Fifty-six percent of the tumours were benign, 52% of flaps were fibular free flaps, while 44% were radial forearm free flaps. Twenty-six percent of the flaps failed while 74% survived. Thirty-nine percent of the flaps experienced complications while an 8% mortality occurred. High-risk cases with comorbidities showed no association to complications or outcomes.

    Conclusion: This study suggests that the circumstance of a limited resource healthcare system impacts negatively on free tissue transfer outcome more than associated comorbidities, provided patients are properly selected.

     

    ORIGINAL ARTICLE

    KNOWLEDGE, ATTITUDE AND CONTROL PRACTICES OF SICKLE CELL DISEASE AMONG ADULTS IN RURAL COMMUNITIES IN UDU LGA, DELTA STATE, NIGERIA

    J. Erusiafe,1 N. S. Awunor,1,2

    1Department of Community Medicine, Delta State University, Abraka, Delta State, Nigeria; 2Department of Community Medicine, Delta State University Teaching Hospital, Oghara, Delta State, Nigeria

    Abstract

    Background: Sickle cell disease (SCD) is an inherited abnormality of the red blood cell characterised by chronic haemolytic anaemia with numerous clinical consequences. It is important for the family, communities, and institutions to have good knowledge of the condition in order to make informed decisions about their reproductive lives, choice of partner, and related health issues. The study therefore seeks to determine the level of awareness, knowledge, attitude, and control practices of sickle cell disease among the residents of selected communities in Udu Local Government Area.

    Methodology: A cross-sectional study was carried out among 400 participants selected using a pretested, self-administered structured questionnaire and analysed using SPSS software, version 25. Ethical approval was obtained from Research and Ethics Committee, Delta State University Teaching Hospital.

    Results: The majority of the participants (85%) were aware of sickle cell disease with the main source of awareness being health care workers (37%), followed by the media (20%). However, 97% had a poor knowledge of the disease. In the study, age (p=0.001), marital status, (p=0.014) and level of education (p=0.003) were significantly associated with knowledge of SCD. The majority, 87.8%, had negative attitudes towards people living with SCD. Regarding control practices, less than two-fifths (61.8%) of the respondents had undergone a genotype test. Most individuals who were Christians, married, and had attained a tertiary level of education had been screened for sickle cell status, and there was a statistically significant association between religion (p<0.001), marital status (p=0.018), level of education (p<0.001) and screening to determine sickle cell status.

    Conclusion: Comprehensive knowledge about SCD was found to be low despite high level of awareness among respondents. If SCD control strategies must yield significant results, there is a need to improve knowledge about SCD, especially among rural communities in Nigeria.

     

    ORIGINAL ARTICLE

    TRIDAX PROCUMBENS LEAF AMELIORATES ALTERED CORPORA CAVERNOSA ACTIVITY IN DIABETIC WISTAR RATS VIA NITRIC OXIDE, K-ATP, AND RECEPTOR-OPERATED CALCIUM CHANNELS

    S. A. Salami, O. M. Adeniran, M. O. Allen, O. A. Oduyemi, H. M. Salahdeen, B. A. Murtala

    Department of physiology, Lagos State University College of Medicine, Lagos, Nigeria

    Abstract

    Background: Tridax procumbens leaf is known for its antidiabetic potential, but its effect on diabetes-induced erectile tissue dysfunction is unclear. This study investigates Tridax procumbens ethanol leaf (TPL) treatment in streptozotocin-induced diabetic male Wistar rats.

    Methods: Thirty adult male Wistar rats were grouped as follows: 1) non-diabetic rats treated with normal saline (control), 2) non-diabetic rats treated with TPL (100 mg/kg), 3) diabetic non-treated rats, 4) diabetic rats treated with TPL (100 mg/kg), and 5) diabetic rats treated with glibenclamide (5 mg/kg). Fasting blood glucose, C-reactive protein, and testosterone levels were measured. Cavernosa contractile responses were assessed using various stimuli with the Ugo Basile data capsule acquisition system.

    Results: TPL treatment significantly reduced fasting blood sugar in diabetic rats. Serum C-reactive protein was notably elevated in diabetic non-treated rats compared to diabetic + TPL co-treated rats. Serum testosterone levels were significantly reduced in the diabetic non-treated group but were higher in the control and diabetic + TPL co-treated groups. Cavernosa tissue relaxation responses to acetylcholine were significantly enhanced in diabetic + TPL co-treated rats, indicating improved NO-mediated relaxation. Calcium ion influx-mediated contraction of cavernosa tissue was significantly inhibited in both the diabetic + TPL co-treated and non-diabetic TPL-treated groups compared to diabetic non-treated rats, suggesting modulation of impaired cavernosa activity.

    Conclusion: TPL treatment in streptozotocin-induced diabetic rats enhanced cavernosa activity by improving NO, guanylyl cyclase, and ATP-sensitive potassium channels while inhibiting receptor-operated calcium channels. TPL's anti-inflammatory, antioxidant, and androgenic properties contribute to this modulation of cavernosa activity in diabetes.

     

    ORIGINAL ARTICLE

    COMPARISON OF A 3D-PRINTED HIGH VOLUME EVACUATION TIP WITH TWO INTRAORAL EVACUATOR TIPS FOR PERFORMANCE DURING DENTAL PROCEDURES: A BENCHTOP PROCEDURE

    T. A. Yemitan,1 O. A. Adenuga-Taiwo,2 A. M. Ladeji,3 A. O. Awotile,4 S. A. Kareem5

    1Senior Lecturer, Department of Child Dental Health, Faculty of Dentistry, Lagos State University College of Medicine, Lagos, Nigeria; 2Senior Lecturer, Department of Restorative Dentistry, Faculty of Dentistry, Lagos State University College of Medicine, Lagos, Nigeria; 3 Senior Lecturer, Department of Oral Pathology and Oral Medicine, Faculty of Dentistry, Lagos State University College of Medicine, Lagos, Nigeria; 4 Senior Lecturer, Department of Restorative Dentistry, Faculty of Dentistry, Lagos State University College of Medicine, Lagos, Nigeria; 5 Dental Student, Faculty of Dentistry, Lagos State University College of Medicine, Lagos, Nigeria.

    Background: The pandemic of coronavirus disease has allowed dental experts to reconsider how they manage infections while administering treatments. Established protocols advise the use of high-capacity suction devices for procedures that create aerosols in dental practise. Lately, the spread of COVID-19 has become a significant worry in dental offices, primarily because procedures generate contaminated aerosols and tiny saliva droplets, leading to possible transmission.

    Methodology: This study compared the performance of three suction tips of different sizes and shapes in a bench top experiment. The suction performance and breadth of suction of a prototype 3D printed high volume evacuator tip, a saliva ejector and a standard high volume evacuator tip were compared using timed water test, salt, and talc powder tests.

    Results: Using analysis of variance and Turkey’s post hoc tests, both the prototype and standard high volume evacuator tips exhibited a significant increase in water flow rate (P < 0.001) compared with that of the saliva ejector. However, the results showed no statistically significant difference in water flow rate between the prototype and the standard high volume evacuator tips (P = 0.362). In addition, a statistically significant difference was observed in the width of suction of salt and talc powder, the prototype tip had the widest breadth of suction while the saliva ejector had the narrowest breadth (P < 0.001).

    Conclusions: Within the study limitation, the study results showed that the prototype high volume evacuator tip performed better than the conventional HVE in suction breadth, but both are similar in flow rate performance. Hence, utilising the prototype tip for isolation during dental procedures could potentially decrease the risk of exposure to pathogens in the oral cavity.

     

    ORIGINAL ARTICLE

    CARDIOEMBOLIC STROKE AFTER KIDNEY TRANSPLANTATION: A RARE COMPLICATION AND LOCAL MULTI-DISCIPLINARY MANAGEMENT EXPERIENCE

    M. Amisu,1,2 S. Sotubo,2 A. Sanda2 A. Odeyemi2, O. Oladimeji2, A. Adekoya1,2

    1Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria; 2Division of Nephrology Unit, Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria.

    Abstract

    Kidney transplant (KT) remains the definitive renal replacement therapy in patients with end-stage renal disease. Studies have shown that cardiovascular complications are the commonest reasons for increased morbidity and mortality. Cardioembolic stroke in KT patients accounts for about 8%. Other less related central nervous system complications include the use of immunosuppressive agents, post-transplant lymphoproliferative disease (PTLD), and viral infections (CMV). In this index case, we present the experience of our teaching hospital, where a 37-year-old woman developed a rare cause of stroke a year after KT. The cardioembolic stroke was confirmed by echocardiography, MRI brain, haematology and serology tests. The patient was managed by multi-disciplinary specialists with fair clinical responses.

     

  • Annals of Clinical Sciences
    Vol. 8 No. 1 (2023)

    ORIGINAL ARTICLE

    MANDIBULAR RECONSTRUCTION ALGORITHM USING ILIAC CREST BONE GRAFT AND VASCULARISED FIBULA FLAP

     E. Okoturo,1,2 B. Ogunbanjo3

     1Head and Neck Cancer Division, Oral and Maxillofacial Surgery Department, Lagos State University Teaching Hospital (LASUTH), Lagos, Nigeria; 2Lagos State University College of Medicine (LASUCOM), Lagos, Nigeria; 3Child Dental Health Department, Lagos State University College of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.

    Abstract

    Background: The study aim to describe the science behind a novel reconstructive algorithm that dictates the reconstruction and outcome of a benign mandibular defect based on the potential impact from a resected vertical ramus, by presenting cases using either iliac crest bone grafts (ICB) or vascularised fibula flaps (VFF).

    Methodology: This is a retrospective study of mandibular reconstruction. We followed a reconstruction algorithm briefly described as, ICB indicated for lateral and hemi-mandibular defect and VFF for antero-lateral or bilateral-defect. Data collated included demographic, histopathology, types of mandibulectomy or defects, types of reconstruction, clinical outcomes and complications. Clinical outcomes were evaluated in terms of function and aesthetics, and assessed using post-operative panoramic images and standardized questionnaire. Statistical analysis was by percentages, mean, and post-operative complication predictors (multivariate-analysis).
    Results: Thirty-five subjects were recruited for this study, with type II Schultz et al. classification being the prevalent mandibular defect in 16 (46%) cases. Twenty-three out of 35 cases underwent ICB while 12 out of 35 cases underwent VFF reconstruction. Functional-aesthetic outcomes were adjudged good/acceptable in all cases. 70% of cases in both groups were free of complications with infection being the highest complication in the ICB group and wound dehiscence in the VFF groups. While there was a causal relationship between defect size and complications / outcome, our analysis showed defect size (p<0.06) and bone length (p<0.12) to be statistically insignificant with respect to their association with increased complication.

    Conclusion: In conclusion, this reconstructive algorithm for the reconstruction of benign mandibular defects is simple, effective, and broadly applicable especially in limited resource areas.

     

    ORIGINAL ARTICLE

    EVALUATION OF PROTEIN C LEVELS IN SICKLE CELL ANAEMIA PATIENTS IN STEADY STATE AND CRISIS AT THE LAGOS STATE UNIVERSITY TEACHIHNG HOSPITAL, LAGOS, NIGERIA

     E. I. Uche,1 O. O. Kalejaiye,2 F. O. Olowoselu,3 T. A. Ekwere,4 R. A. Bamiro,5 O. A. Kareem,6 A. Benjamin,7 A. Suleiman,7 H. A. Odebiyi,8 A. Balogun,9 A. Akinbami1

     

    1Department of Haematology and Blood Transfusion, Lagos State University College of  Medicine, Ikeja, Lagos; 2Department of Medicine, College of Medicine, University of Lagos, Lagos; 3Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos; 4Department of Haematology, University of Uyo, Akwa Ibom; 5Department of Haematology and Blood Transfusion, Lagos State University Teaching Hospital. Lagos; 6Department of Medicine, Geriatric Unit, Faculty of Clinical Sciences, Lagos State University College of Medicine, Lagos; 7Department of Haematology and Blood Transfusion, Ahmadu Bello University, Zaria, Kaduna State; 8Department of Haematology, Federal Medical Center, Birnin Kudu, Jigawa State; 9Newday Medical Centre, Akure, Ondo State.

     

    Abstract

    Background: Sickle cell anaemia is a hypercoaguble state and is associated with thrombotic episodes such as ischaemic stroke and venous thromboembolic phenomenon. Protein C is a natural Vitamin-K dependent glycoprotein that inactivates Factors V and VIII using Protein S as a cofactor and thus resulting in anticoagulation.

    This study measured serum Protein C activity in SCA patients during vaso-occlusive crisis and in steady-state, and this was compared with the activity levels in HbAA controls.

    Methodology: This was an analytical prospective study which comprised of 30 HbSS patients and 30 HbAA controls. Protein C levels were measured using ELISA in the SCA group during crisis and in the HbAA control group; When the HbSS patients were in steady state, Protein C levels were then measured again.

    Results: Protein C levels were highest in the HbAA control group (0.73 + 0.08 ng/mL) followed by the HbSS patients in steady state (0.63 + 0.07 ng/mL) and lowest in the HbSS patients in crisis (0.49 + 0.11 ng/mL). This difference was statistically significant with p= 0.001.

    Conclusion: Protein C levels are reduced in HbSS patients when compared with HbAA controls, and the levels are lower during a vasoocclusive crisis compared with steady state.

     

    ORIGINAL ARTICLE

    KELOID DISEASE: PROSPCETIVE CROSS-SECTIONAL STUDY OF CLINICOEPIDEMIOLOGICAL AND HEALTH RELATED QUALITY OF LIFE AT A TERTIARY CENTER

     E. L. Anaba,1 O. Cole-Adeife2

    1Department of Medicine, Lagos State University College of Medicine/ Lagos State University Teaching Hospital, Lagos, Nigeria; 2Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria

    Abstract

    Background: Keloid disease and its impact on the quality of life of patients is not frequently documented. The objective of this study was to document the epidemiologic and clinical features of keloid and its impact on the quality of life of patients.

    Methodology: A prospective cross-sectional study of 64 adult keloid disease patients was conducted over a one-year period following informed consent and ethical approval at a tertiary centre. Patients were clinically evaluated and quality of life was assessed using the dermatology life quality index (DLQI). Data was analysed using SPSS version 23.0.

    Results: The dermatology clinic prevalence of keloid was 11.6%. The mean age of those who had keloid was 34.34 ± 15.15 years and they were 60.9% female. The mean duration and mean age at onset of keloid were 5.98 ± 8.73 and 28.38 ± 13.84 years respectively. The reason for seeking treatment was dislike of the keloid lesions in 65.6%. Symptoms of pain and pruritus were reported in 51.6% and 92.2% respectively. The mean DLQI score was 6.84 ± 4.94. Quality of life was impaired in 92.2% patients and this was a small effect in 40.6%.  The only factor which correlated with Quality of life (QOL) impairment was the number of keloids; p=0.021.

    Conclusion: Keloid is a disease of the young, has a female preponderance and occur more on the chest and face. Quality of life is negatively affected and patients seek treatment because of embarrassment, dislike for the keloid lesions and the multiplicity of lesions.

     

    ORIGINAL ARTICLE

    MANAGEMENT OF HAND DEFECT WITH PEDICLED SUPERFICIAL CIRCUMFLEX ILIAC PERFORATOR (SCIP) FLAP:  NOH, DALA KANO AND LASUTH, IKEJA EXPERIENCE

    A. Ajani,1 M. F. Alimi,2 A. A. Adesina,1 A. M. Waziri,2 H. M. Suleiman,2 K. A. Gbadamasi,2 A. I. Bolaji,2 S. A. Atoyebi2

     1Plastic and Reconstructive Surgery Unit, Lagos State University Teaching Hospital, Ikeja. Lagos, Nigeria; 2Plastic and Reconstructive Surgery unit, National Orthopedic Hospital Dala, Kano, Nigeria

    Abstract

    Background: Superficial circumflex perforator (SCIP) flap was first popularized in 2004 by Koshima. Its versatility has been employed as option for coverage of hand defect either as a pedicle or free flap. This flap can also be employed as a workhorse flap for coverage for large hand defects, it’s easy to harvest, with negligible donor site morbidity. This study aimed to share our experience with the use of SCIP flap for reconstruction of hand defect.

    Methodology: A retrospective study of 21 patients with hand defects who had ipsilateral SCIP flap coverage between May 2018 and April 2021.The demographic characteristics, aetiology of hand defect, distance of perforator from superficial circumflex iliac artery (SCIA) as identified using handheld doppler and outcome were analysed.  All cases were done in 3 stages (elevation, division and in setting).

    Results: 66.7% of patients were males (n=14). The defect was mostly posttraumatic (71.4%). The defects range from 6x 4 cm to 14x8cm in their widest dimensions. A pedicled SCIP was used in all cases. The SCIA perforator was within 5cm to the pubic tubercle. Only in 3 cases (14.3%) was the donor site closed with skin graft. Post-operative complication was seen in 2 patients as flap tip necrosis. All the patients did not require flap debulking. Mean follow-up period was 9months

    Conclusion: SCIP flap is valuable in coverage of extensive hand defects, often without need for debulking surgery and minimal donor site morbidity.

     

    ORIGINAL ARTICLE

     KNOWLEDGE, ATTITUDE AND PRACTICE OF EXCLUSIVE BREASTFEEDING AMONG MARKET WOMEN IN OYINGBO MARKET, LAGOS, NIGERIA

     T. F. Olufunlayo,1,2 O. O. Adebiyi,1 F. A. Olatona1

     1Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos, Nigeria; 2Department of Community Health, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.

    Abstract
    Background: Exclusive breastfeeding (EBF) up until six months is the optimal way of feeding infants.
    Despite the numerous benefits of exclusive breastfeeding, its practice is still sub-optimal globally. This
    study was conducted to assess the knowledge, attitude and practice of exclusive breastfeeding among
    market women in Oyingbo market, Lagos.
    Methodology: This was a cross-sectional descriptive study involving women traders at Oyingbo Market
    within the reproductive age group (15-49yrs) and having one or more children under five years of age.
    Consecutive sampling technique was employed; respondents were recruited consecutively from the stalls along each street within the market until the required sample size was attained. An interviewer-administered structured questionnaire was used to collect data, and data was analyzed using Epi-Info Version 7. Ethical approval was obtained from the Health Research Ethics Committee of the Lagos University Teaching Hospital, Idi-Araba.
    Results: Majority of the respondents were married (97.3%), between 21 and 40 years of age (93.3%), had secondary school as their highest level of education (61.6%), were Yoruba (79.9%), practiced Islam
    (65.2%), and had between 1 - 2 children (51.3%). Most of the respondents (96%) were aware of exclusive breastfeeding, with health care workers being cited most as their source of information (92.1%). About half of the respondents (51.5%) knew the correct definition and duration of exclusive breastfeeding as giving breast milk only for 6 months. All the respondents stated that breast milk was the best milk for the baby, and four-fifths knew that exclusive breastfeeding is sufficient for the first six months of baby’s life. All the respondents (100%) initiated breastfeeding although only two-thirds (63.8%) reported initiation within an hour after delivery. Only 37.5% of the respondents practiced exclusive breastfeeding for 6 months.
    Conclusion: Although the knowledge of exclusive breastfeeding was high and attitude was positive, the prevalence of exclusive breastfeeding was low among mothers in Oyingbo market, Lagos. Health
    education, especially peer education on the benefits of exclusive breastfeeding, and other group-based
    interventions would be beneficial in improving exclusive breastfeeding rates. An enabling environment for breastfeeding within the markets is also an important area for consideration.

     

    ORIGINAL ARTICLE
    FEASIBILITY, SAFETY AND EFFECTIVENESS OF SUBDURAL TRANEXAMIC ACID IRRIGATION IN THE MANAGEMENT OF CHRONIC SUBDURAL HEMATOMA: A PRELIMINARY STUDY

    O. E. Idowu,1,2 A. S. Adeniran,2 J. O. Idowu3

    1Department of Surgery, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria; 2Division of Neurological Surgery, Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria. 3Finnih Medical Centre, Ikeja GRA, Lagos, Nigeria;

    Abstract

    Background: The optimal management of chronic subdural hematoma (CSH) remains a topic of debate, as there is a lack of consensus on the optimal treatment approach. Topical application of tranexamic acid (TXA) to bleeding surfaces has shown potential in inhibiting local fibrinolysis and reducing bleeding, with minimal systemic effects. This study aims to evaluate the feasibility, safety, and effectiveness of subdural TXA irrigation in the management of CSH.

    Methodology: A prospective analysis of the clinical data from 18 patients with CSH was conducted with a minimum 6-week period of follow-up. Clinical and radiological follow-up was performed at regular intervals (1 week, 3 and 6 weeks after surgery) to monitor recurrence and neurological improvement. The primary outcome measure was the recurrence of CSH requiring surgical intervention, while secondary outcomes included Clavien-Dindo grade (CDG) and neurological outcome assessed using the Markwalder grading scale and Glasgow Outcome Scale Extended scores at 6 weeks post-operatively.

    Results: The study population consisted of 11 males, with a mean age of 59.5 years (range: 30-88 years). There were no cases of CSH recurrence or mortality observed. All patients exhibited a CDG score of less than 3 and significant neurological improvement at 6 weeks post-surgical intervention.

    Conclusions: Our preliminary findings demonstrate acceptable postoperative outcomes with the off-label use of TXA for subdural irrigation in CSH. These results suggest that subdural irrigation of TXA could be considered as a primary surgical treatment option for patients with CSH. This study highlight the promising nature of this novel approach and emphasize the need for future prospective randomized controlled studies to confirm these preliminary data.

  • Annals of Clinical Sciences
    Vol. 7 No. 2 (2022)

    ORIGINAL ARTICLE

    ASSESSMENT OF SCHOOL HEALTH PROGRAMME IN PRIVATE SCHOOLS IN IKEJA LOCAL GOVERNMENT AREA OF LAGOS STATE

    O. O. Goodman, F. A. Olatona, M. Y. Ijadunola, F. C. Anyawu, A. O. Lawal-Akapo, O. O. Baruwa, B. E. Aseyan

    Background: Vitiligo is one of the common acquired pigmentary disorders. However, studies on its clinical profile are few. The aim of this study was to document the clinical and sociodemographic …

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    ORIGINAL ARTICLE

    THE PREVALENCE OF PSYCHO ACTIVE SUBSTANCE USE AND ASSOCIATED RISK FACTORS AMONG UNIVERSITY UNDERGRADUATES IN LAGOS SOUTHWEST NIGERIA

    B. S. Osalusi, O. Koleowo, L. Ogunjimi, T. O. Afe, O. Ogunsemi, A. O. J. Agboola, M. A. Deji-Agboola, A. Ale, C. F. Osalusi, B. Nayisavye

    Background:   Psychoactive substance abuse is a global problem and youthful populations are more vulnerable particularly in developing countries where circumstances may be favourable for it. …

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    ORIGINAL ARTICLE

    CORRELATING P-SELECTIN AND HAEMOGLOBIN F LEVELS WITH NUMERICAL PAIN SCORE IN SICKLE CELL ANAEMIA PATIENTS IN LAGOS STATE, NIGERIA

    O. I. Adeyemi, A. A. Akinbami, E. I. Uche, A.O Hassan, R. A. Bamiro, I. N. Ibrahim, A. M. Suleiman, A. Benjamin, C. D. Anaduaka

    Background: The pathology of bone pain, vaso-occlusive crisis (VOC) in sickle cell anaemia (SCA) is multi-factorial and includes endothelial damage, abnormal cellular adhesion, and chronic inflammation with an …

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    ORIGINAL ARTICLE

    LUNG FUNCTION PATTERN IN ASTHMA PATIENTS ATTENDING A TERTIARY FACILITY IN LAGOS

    O. T. Ojo

    Background: Foreign bodies in aero digestive tract occur frequently and they are of acute emergency when impacted in the larynx, trachea and of less emergency when impacted in the oesophagus. …

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    ORIGINAL ARTICLE

    ACCEPTANCE OF A COVID-19 VACCINE IN SOUTHWEST NIGERIA: A CROSS-SECTIONAL STUDY

    B. S. Osalusi, O. Koleowo, L. Ogunjimi, T. O. Afe, O. Ogunsemi, A. O. J. Agboola, M. A. Deji-Agboola, A. Ale, C. F. Osalusi, B. Nayisavye

    Background: Several vaccines are being administered in response to the 2019 coronavirus disease (COVID-19) pandemic. This study was conducted to assess the acceptance of COVID-19 vaccine, among the general population in south west Nigeria. …

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    CASE REPORT

    A MIGRATING SWALLOWED FISH BONE CAUSING NECK ABSCESS AND INTERNAL JUGULAR VEIN THROMBOSIS: A CASE REPORT

    A. P. Adeyinka, V. Adekoya, O. Olubi, I. Fasina, E. N. Jebin, O. M. Oladimeji, S. Yahaya, A. Adesanya

    We present a 42 year old woman who had fish bone impaction while eating .She subsequently used, among others, swallowing of big food bolus to push it down which failed. She presented here after two weeks …

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  • Annals of Clinical Sciences
    Vol. 7 No. 1 (2022)

    REVIEW ARTICLE

    HEALTH PROFESSIONS EDUCATION FOR NIGERIAN MEDICAL SCHOOLS

    TA JOHN

     

    ORIGINAL ARTICLES

    THE IMPACT OF COVID – 19 PANDEMIC ON OPHTHALMIC SERVICES - A COMPARATIVE STUDY AT THE LAGOS STATE UNIVERSITY TEACHING HOSPITAL IN NIGERIA

    B. G. BALOGUN, M. M. BALOGUN, B. J. ADEKOYA, R. A. NGWU, M. O. SALAMI

     

    CUTANEOUS MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AT INITIAL DIAGNOSIS AT A RHEUMATOLOGY CLINIC IN LAGOS, NIGERIA

    E. L. ANABA, O. COLE-ADEIFE, H. OLAOSEBIKAN, O. O. DAWODU

     

    THE VALUE OF PERNASAL BIOPSIES IN THE MANAGEMENT OF NASOPHARYNGEAL TUMOURS IN RESOURCE POOR ENVIRONMENT

    O. O. OLUBI, A. S. ADOGA, O. G. B. NWAORGU, C. MGBACHI, I. TURAKI, F. A. OBEBE, S. OCHENEHI

     

    CASE REPORTS

    BEHÇET’S DISEASE: CASE REPORT AND REVIEW OF THE LITERATURE

    S. BASHORUN, R. NGWU, H. OLAOSEBIKAN, A. O. BASHORUN

     

    FREE VASCULARIZED FIBULA GRAFT FOR FEMORAL RECONSTRUCTION FOLLOWING SARCOMA RESECTION- A CASE REPORT

    A. O. AJANI, O. OSISANYA, N. OKOH N, M. N. SALIHU, G. O. ONYEJEKWE, A. A. AFOLABI

     

    PROCEEDINGS OF THE 7TH BIENNIAL FACULTY DAY AND SCIENTIFIC CONFERENCE OF FACULTY OF CLINICAL SCIENCES, COLLEGE OF MEDICINE, LAGOS STATE UNIVERSITY, IKEJA, LAGOS, NIGERIA, 2021

    RELATIONSHIP BETWEEN BONE MINERAL DENSITY (BMD) AND BODY MASS INDEX (BMI) AMONG PATIENTS AGED 40 AND ABOVE WITH OSTEOARTHRITIS (OA) OF THE KNEE

    M. O. SHOGA, I. G. AJIBOYE, M. O. KAYODE, S. O. IDOWU, O. S. OLAWOYE, O. A. ADEWOLE

     

    CLINICAL ETHICAL DILEMMAS AND CONFLICTS ENCOUNTERED BY PAEDIATRICIANS IN NIGERIA: A PILOT ONLINE SURVEY

    P. O. UBUANE, A. M. OGUNLEYE, A.U. SOLARIN, I. N. DIAKU-AKINWUMI, B. A. ANIMASAHUN, A. D. KNACKSTEDT

     

    MECHANISMS IN KIGELIA AFRICANA STEM BARK EXTRACT ATTENUATION OF IMPAIRED CONTRACTILE FUNCTION OF THE CORPUS CAVERNOSUM IN STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS

    S. A. SALAMI, I. O. OLADEJI, B. A. MURTALA

     

    PROFILE OF INSULIN RESISTANCE OF PREGNANT WOMEN AT THE LAGOS STATE UNIVERSITY TEACHING HOSPITAL, IKEJA

    J. O. CHIONUMA, I. J. AKINOLA, A. O. DADA, P. O. UBUANE, T. O. KUKU-KUYE, F. D.H. OLALERE

     

    THORACIC ENDOMETRIOSIS SYNDROME: A CASE REPORT

    F. D. H. OLALERE, T. O. KUKU-KUYE, F. M. AKINLUSI, F. A. ADEYEYE

     

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    HEALTH LITERACY AND PREVENTIVE PRACTICES REGARDING HYPERTENSION AMONG TRADERS IN AN URBAN MARKET, LAGOS STATE

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