The MECHANISMS IN KIGELIA AFRICANA STEM BARK EXTRACT ATTENUATION OF IMPAIRED CONTRACTILE FUNCTION OF THE CORPUS CAVERNOSUM IN STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS

CONTRACTILE FUNCTION OF THE CORPUS CAVERNOSUM IN STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS

Authors

  • SA Salami
  • ISLAMIYYAH OLADEJI Lagos state university college of medicine
  • BA Murtala

Abstract

Contractile mechanisms of the corpus cavernosum in streptozotocin-induced diabetic male Wistar rats treated with ethanolic stem bark extract of Kigelia africana (EEKA) was investigated. Cavernosal strips of diabetic/non-diabetic rats treated with EEKA (250 mg/kg) were excised and contractile responses to phenylephrine, CaCl2 influx, and caffeine were determined. Contractile responses after incubation in nicorandil and SNP were also determined. Caffeine and phenylephrine together with incubation in SNP and nicorandil significantly inhibited contractile responses in diabetic+EEKA group. However, CaCl2 significantly enhanced contractile response in diabetic+EEKA group.  KATP and NO pathway may contribute to relaxant action of EEKA on the corpus cavernosum.
 

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Published

30-01-2022

How to Cite

Salami, S., OLADEJI, I., & Murtala, B. (2022). The MECHANISMS IN KIGELIA AFRICANA STEM BARK EXTRACT ATTENUATION OF IMPAIRED CONTRACTILE FUNCTION OF THE CORPUS CAVERNOSUM IN STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS: CONTRACTILE FUNCTION OF THE CORPUS CAVERNOSUM IN STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS. Annals of Clinical Sciences, 7(1), 44–47. Retrieved from https://acsjournal.lasucom.edu.ng/index.php/acs/article/view/93

Issue

Vol. 7 No. 1 (2022): Annals of Clinical Sciences

Section

Proceedings